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Life Science Microfluidics

The Division offers infrastructure and assistance within microfluidics, acoustofluidics, and microfabrication. We can design and develop microsystems for processing of body/bodily fluids, cell sorting, immobilization, and neural electrodes.

Collage of four microfluidic experiments. Photo.
We can work with PDMS/silicone, thermoplastics (polypropylene, polyimide etc), glass, aluminum.

Examples of available technology and past projects:

Miromilling needle. Photo.

Micromilling down to 50 µm. Photolitography down to 5 µm. 3D-printing: Extruder, SLA (400 µm), DLP (10 µm features, 2 µm spots, 5 µm layers). Silicon and glass microfabrication.
Equipment examples: (external links)
Boston Microfabrication MicroArchS230 
SLA (stereo lithography) printer  
Datron Neo Series 2 (Swedish link) 

Gradient maker and output. Illustration/photo.

Gradient generator for Stem Cell regionalization

Modeling neural tube development by differentiation of human embryonic stem cells in a microfluidic WNT gradient, Nature Biotechnology | VOL 38 | November 2020 | 1265–1273.

Fungi migrating in microchip. Microsope photo.

Microfluidic chips provide visual access to in situ soil ecology, COMMUNICATIONS BIOLOGY | (2021) 4:889

Schematic of experimental set-up. Photo/illustration.

Two-Step Acoustophoresis Separation of Live Tumor Cells from Whole Blood (2021) In Analytical Chemistry 93(51). p.17076.

Experimental scheme. Photo/illustration.

Acoustic nanoparticle trapping enables isolation and purification of extracellular vesicles in samples as small as e.g. 10 µL blood plasma.

Experimental schematic. Photo/illustration.

Biogrid—a microfluidic device for large-scale enzyme-free dissociation of stem cell aggregates, Lab Chip, 2011, 11, 3241

Talk to us

Discuss the feasibility of your project with our Project Coordinator:

Martin Bengtsson

martin [dot] bengtsson [at] bme [dot] lth [dot] se (martin[dot]bengtsson[at]bme[dot]lth[dot]se)
 

Managers

Thomas Larell. Portrait photo.
Thomas Laurell

LU Research Portal

Anja Meissner. Portrait photo.
Anja Meissner. Photo: Kenneth Ruona.

LU Research Portal.

Project Group

Axel Tojo, Martin Bengtsson, Johan Nilsson, Thomas Laurell.